Endometrial Receptivity Analysis

The Endometrial Receptivity Analysis also known as ERA test requires an endometrial biopsy and evaluates the status of the woman’s endometrial receptivity to prevent implantation failure.

ERA (Endometrial Receptivity Array) is a molecular diagnostic test to investigate the receptivity of the endometrium. Receptivity of the endometrium is the condition in which the endometrium (uterine lining) is ready for implantation (nesting) of the embryo.

An endometrium is receptive when it is ready for embryo implantation which occurs around days 19-21 in each menstrual cycle of a fertile woman. This period of receptivity is what we call the window of implantation.

The lack of synchronization between the embryo ready to be implanted and endometrial receptivity is one of the causes of recurrent implantation failure. This is why it is imperative to assess the endometrium in order to determine the optimal day for embryo transfer in such cases.

The ERA test analyses the expression levels of 248 genes linked to the status of endometrial receptivity, using RNA sequencing taken from the endometrial tissue.

Normally, the endometrium is evaluated by using ultrasound that can assess only height and texture of the endometrium. ERA offers a new option that increases the likelihood of pregnancy for couples with repeated failure of implantation. The test evaluates the right time for implantation.

ERA test is carried out optimally during the cycle preceding the one in which the embryo transfer is planned. The tissue for the test is obtained by biopsy of the endometrium. The result will therefore enable us to set the appropriate date of embryo transfer individually for each patient.

ERA test is highly sensitive and enables detection of the receptivity of the endometrium. Here at Cyprus HOPE IVF we recommend ERA as a good choice for women with repeated unsuccessful embryo transfers.